UCLA Brain Mapping Center

Publications

Topographical and temporal specificity of human intraoperative optical intrinsic signals.

Cannestra AF; Black KL; Martin NA; Cloughesy T; Burton JS; Rubinstein E; Woods RP; Toga AW;
Neuroreport. 1998-Aug-3; 9(2557-63):11
 
The goal of this study was to determine the topographical and temporal specificity of neuronal and vascular responses using an intraoperative optical technique (iOIS). The face, thumb, index, and middle fingers were stimulated individually to obtain separate maps of cortical activation. Peak optical responses provided unique, non-overlapping cortical brain maps. Non-peak signals were more dispersed and produced overlapping responses from different digits. Peak iOIS responses colocalized with electrocortical stimulation mapping and evoked potentials. Temporally, we observed statistically significant specificity corresponding to sequential cortical activation during early optical signals (500-1750 ms), but later perfusion responses were non-specific. To our knowledge, this is the first report of either topographical specificity in overlapping spatial patterns, and/or temporal specificity in early perfusion profiles. These results therefore may have significant implications for other perfusion dependent functional imaging techniques.
 
PMID: 9721932    doi: 10.1080/713754339
 

BMAP Author