UCLA Brain Mapping Center

Publications

PET imaging of neuropathology in tauopathies: progressive supranuclear palsy.

Kepe V; Bordelon Y; Boxer A; Huang SC; Liu J; Thiede FC; Mazziotta JC; Mendez MF; Donoghue N; Small GW; Barrio JR;
Journal of Alzheimer's disease : JAD. 2013-Jan-1; 36(145-53):1
 
Currently [18F]FDDNP is the only PET imaging probe with the ability to visualize hyperphosphorylated tau fibrillar aggregates in living subjects. In this work, we evaluate in vivo [18F]FDDNP labeling of brain neuropathology, primarily tau fibrillar aggregates, in patients with progressive supranuclear palsy (PSP), a human tauopathy usually lacking amyloid-β deposits.
 
PMID: 23579330    doi: 10.3233/JAD-130032
 

BMAP Author