UCLA Brain Mapping Center

Publications

Mapping biochemistry to metabolism: FDG-PET and amyloid burden in Alzheimer's disease.

Mega MS; Chu T; Mazziotta JC; Trivedi KH; Thompson PM; Shah A; Cole G; Frautschy SA; Toga AW;
Neuroreport. 1999-Sep-29; 10(2911-7):14
 
We evaluated the relationship between amyloid-beta protein (A beta) concentration and the metabolic abnormality in an Alzheimer's disease (AD) patient as measured by [18F]fluorodeoxyglucose positron emission tomography (FDG-PET). Across most regions there were significant inverse correlations among FDG-PET intensity values and both insoluble. The temporal lobe samples showed no significant correlation between FDG-PET values and A beta deposition. Findings support A beta as contributing to the hypometabolism in regions of the AD brain that are still relatively viable metabolically; those regions with chronic pathologic damage, such as temporal cortex, may have other factors that contribute to metabolic deficits.
 
PMID: 10549796    doi: 10.1073/pnas.090106797
 

BMAP Author