UCLA Brain Mapping Center

Publications

Improved signal-to-noise in PET activation studies using switched paradigms.

Cherry SR; Woods RP; Doshi NK; Banerjee PK; Mazziotta JC;
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1995-Feb; 36(307-14):2
 
PET activation studies employing the autoradiographic technique and 15O-water or 15O-butanol use the difference between images acquired under baseline conditions and during activation to detect focal changes in cerebral blood flow which occur upon stimulus presentation. Typically, the activating task or baseline conditions are maintained throughout the entire imaging period. Simulations of the kinetics of these freely diffusible tracers suggest there may be an advantage to switching between activation and baseline conditions during the course of the study which results in images which maximize the difference signal rather than seeking to quantitate blood flow. We examine the potential of these switched protocols to increase signal-to-noise (S/N) in PET activation studies.
 
PMID: 7830136    doi: 10.1002/ana.410370605
 

BMAP Authors