UCLA Brain Mapping Center

Publications

Hippocampal neuronal loss and regional hypometabolism in temporal lobe epilepsy.

Henry TR; Babb TL; Engel J; Mazziotta JC; Phelps ME; Crandall PH;
Annals of neurology. 1994-Dec; 36(925-7):6
 
The pathophysiology of widespread interictal hypometabolism in temporal lobe epilepsy is unknown but might reflect neuronal loss and diaschisis. We found no significant correlation between any cortical region's metabolism on preoperative [18F]fluorodeoxyglucose positron emission tomography and neuronal density of resected hippocampi in 40 patients. We conclude that hippocampal neuronal loss and diaschisis cannot account for the regional interictal hypometabolism of temporal lobe epilepsy.
 
PMID: 7998782    doi: 10.1002/ana.410360620
 

BMAP Author