UCLA Brain Mapping Center

Publications

Age-related morphology trends of cortical sulci.

Kochunov P; Mangin JF; Coyle T; Lancaster J; Thompson P; Rivière D; Cointepas Y; Régis J; Schlosser A; Royall DR; Zilles K; Mazziotta J; Toga A; Fox PT;
Human brain mapping. 2005-Nov; 26(210-20):3
 
The age-related trends of the width and the depth of major cortical sulci were studied in normal adults. Ninety healthy subjects (47 males, 43 females) age 20-82 years were evaluated. Measurements of average sulcal width and depth in 14 prominent sulcal structures per hemisphere were performed with high-resolution anatomical MRI. The average sulcal width increased at a rate of about 0.7 mm/decade, while the average sulcal depth decreased at a rate of about 0.4 mm/decade. Sulcal age-related trends were found to be highly influenced by gender in the superior temporal, collateral, and cingulate sulci (P < 0.05), with males showing more pronounced age-related change in sulcal width than females. Sulcal structures located in multimodal cortical areas showed more profound age-related changes than sulcal structures in unimodal cortical areas (P < 0.05).
 
PMID: 16161162    doi: 10.1002/hbm.20198
 

BMAP Author